First-in-human phase I study of Atu027, a liposomal small interfering RNA formulation, targeting protein kinase N3 (PKN3) in patients with advanced solid tumors

Autor:	Dirk Strumberg, Christiane Vank, Oliver Keil, Jörg Kaufmann, Joachim Drevs, Klaus Giese, Ansgar Santel, U. Traugott, Beate Schultheis
Rok vydání:	2011
Předmět:	Cancer Research Small interfering RNA Liposome business.industry First in human PKN3 Phase i study Oncology RNA interference Gene expression Cancer research Medicine lipids (amino acids peptides and proteins) business Protein kinase A
Zdroj:	Journal of Clinical Oncology. 29:3057-3057
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2011.29.15_suppl.3057
Popis:	3057 Background: Atu027 is a novel RNAi therapeutic based on cationic lipoplexes containing chemically stabilized siRNAs, which targets PKN3 gene expression in the vascular endothelium. PKN3 acts a...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::16ca5fcdc13627c748306d73da683df6 https://doi.org/10.1200/jco.2011.29.15_suppl.3057 Zobrazit plný text záznamu