Bioactive components of Chinese herbal medicine enhance endogenous neurogenesis in animal models of ischemic stroke
| Autor: | Zi Xian Chen, Xia Wei Zheng, Shuang Chen, Yan Li, Guo-Qing Zheng, Lin Lu, Wen Ting Yang, Ji Huang Li, Xiao-guang Zhang, Yong Gu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Glial fibrillary acidic protein biology Traditional medicine business.industry Neurogenesis General Medicine Nestin medicine.disease Neural stem cell Doublecortin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine biology.protein Medicine Biomarker (medicine) NeuN business Stroke 030217 neurology & neurosurgery |
| Zdroj: | Medicine. 95:e4904 |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000004904 |
| Popis: | BACKGROUND Chinese herbal medicine (CHM) has been used to treat stroke for thousands of years. The objective of the study is to assess the current evidence for bioactive components of CHM as neurogenesis agent in animal models of ischemic stroke. METHODS We searched PubMed, China National Knowledge Infrastructure, WanFang Database, and VIP Database for Chinese Technical Periodicals published from the inception up to November 2015. The primary measured outcome was one of neurogenesis biomarker, including Bromodeoxyuridine (BrdU), Nestin, doublecortin (DCX), polysialylated form of the neural cell adhesion molecule (PSA-NCAM), neuronal nuclear antigen (NeuN), and glial fibrillary acidic protein (GFAP). RESULTS Thirty eligible studies were identified. The score of quality assessment ranged from 2 of 10 to 7 of 10. Compared with controls, 10 studies conducting neurobehavioral evaluation showed significant effects on bioactive components of CHM for improving neurological deficits score after ischemic insults (P |
| Databáze: | OpenAIRE |
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