Easily readable palindromic sequence-defined polymers built by cascade thiol-maleimide Michael couplings

Autor:	Xiaohuan Cao, Qiunan Shi, Yuxuan Xu, Jingqiu Lu, Xiulin Zhu, Yajie Zhang, Suhua Duan, Zhengbiao Zhang, Lihua Hu, Zhihao Huang
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Polymers and Plastics Computer science Organic Chemistry Synthon Palindrome Bioengineering Polymer Biochemistry Combinatorial chemistry chemistry.chemical_compound Exponential growth chemistry Cascade Maleimide DNA Palindromic sequence
Zdroj:	Polymer Chemistry. 11:5974-5980
ISSN:	1759-9962 1759-9954
DOI:	10.1039/d0py01088j
Popis:	Palindromic sequence-induced specific and genetic functions widely exist in biological systems. Nevertheless, the study of synthetic palindromic sequence-defined polymers has received scarce attention due to the challenge of efficient synthesis. Herein, we demonstrated cascade thiol-maleimide Michael couplings (CTMMC) as an efficient chemistry to access palindromic sequences. Taking bromomaleimide as the synthon, the CTMMC enabled the construction of an array of palindromic sequences at an accelerated growth rate via an iterative exponential growth strategy. Moreover, owing to the synergetic cleavages of two C–S bonds located in dithiosuccinimide linkages, the palindromic sequences were easily readable (i.e., decipherable) by tandem mass spectrometry. The CTMMC chemistry endowed structural versatility and diversity to the palindromic sequences, thereby uncovering many potential applications, such as anti-counterfeiting labeling and item identification like artificial “DNA”.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::16bc0e1a46daf8155018d94a8420cecd https://doi.org/10.1039/d0py01088j Zobrazit plný text záznamu