| Popis: |
Background: Myocardial infarction (MI) has unfavourable effect on structural and functional properties of the myocardium, referred to as cardiac remodeling. Left ventricular (LV) mass, LV mass index (LVMI) and relative wall thickness (RWT) are important predictors of cardiac remodeling. In this study, we investigated the effect of candesartan treatment in comparison with zofenopril treatment on echocardiographic indices of cardiac remodeling in post MI patients. Material and Methods: In this prospective study, patients who underwent successful percutaneous coronary intervention were randomly assigned to a candesartan or zofenopril treatment. After randomization, echocardiographic indices of cardiac remodeling including LV mass, LVMI and RWT were evaluated before the start of treatment along with one month and six month follow ups. Results: According to our study, candesartan group showed significant reduction of estimated LV mass and LVMI at six month follow up visit compared to baseline values (199.53∓38.51 g vs 212.69∓40.82 g ; 99.05 g/m2 (90.00~116.5) vs 106.0 g/m2 (96.0~123.00), p |
