Loss of sulfite oxidase activity and outer membrane damage in rat hepatic mitochondria during CCl4 poisoning

Autor:	Rebecca Head, Timothy Pastoor, Peter Drenchko, Isadore A. Bernstein, Michael J. Brabec
Rok vydání:	1977
Předmět:	Biophysics CCL4 Cell Biology Oxidative phosphorylation Mitochondrion Biology Biochemistry Cell biology chemistry.chemical_compound medicine.anatomical_structure chemistry Cytoplasm Sulfite oxidase Hepatocyte medicine Semipermeable membrane Bacterial outer membrane Molecular Biology
Zdroj:	Biochemical and Biophysical Research Communications. 76:189-195
ISSN:	0006-291X
DOI:	10.1016/0006-291x(77)91685-0
Popis:	The activity of sulfite oxidase increased in intact rat hepatic mitochondria and decreased in solubilized mitochondria during poisoning by CCl 4 . During acute damage the sulfite oxidase activity of the post-mitochondrial supernate increased, while the total activity in the hepatocyte declined. Thus, the outer membrane loses its selective permeability to macromolecules coincident with the decline of oxidative phosphorylation. In recovery, normal levels of activity in intact mitochondria and in the hepatocyte were restored, but a large proportion of the total activity remained in the cytoplasm. The data suggest that outer membrane repair and replacement of sulfite oxidase are involved in the restoration of mitochondrial structure and function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::169c8199f40c6899d412136bc35ea6af https://doi.org/10.1016/0006-291x(77)91685-0 Zobrazit plný text záznamu