| Popis: |
The activity of sulfite oxidase increased in intact rat hepatic mitochondria and decreased in solubilized mitochondria during poisoning by CCl 4 . During acute damage the sulfite oxidase activity of the post-mitochondrial supernate increased, while the total activity in the hepatocyte declined. Thus, the outer membrane loses its selective permeability to macromolecules coincident with the decline of oxidative phosphorylation. In recovery, normal levels of activity in intact mitochondria and in the hepatocyte were restored, but a large proportion of the total activity remained in the cytoplasm. The data suggest that outer membrane repair and replacement of sulfite oxidase are involved in the restoration of mitochondrial structure and function. |
