Réaction De Diarylnitrilimines Sur Des 2-Arylidene-Tetralin-1-Ones Substituées. Influence Des Facteurs Conformationnels Sur La Diastéréochimie De La Réaction

Autor:	Joël Vebrel, Marie-France Mercier, Bernard Laude, Kabula Tshiamala, Abdelali Kerbal
Rok vydání:	2010
Předmět:	Stereochemistry Chemistry General Chemistry Medicinal chemistry Cycloaddition Tetralones
Zdroj:	Bulletin des Sociétés Chimiques Belges. 100:159-168
ISSN:	0037-9646
DOI:	10.1002/bscb.19911000209
Popis:	Spiropyrazolines have been synthetized by 1,3-dipolar cycloaddition of some 2-arylidene-1 -tetralones with diarylnitrilimines. It is shown that ring-closure reaction is regiospecific. The diastereoselectivity of the reaction is strongly dependent on the conformational disposition of the substituents of the dipolarophile. The relative configuration and conformation of the products have been determined by means of protonic magnetic resonance measurements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::169af21f43d163212b73121b27830912 https://doi.org/10.1002/bscb.19911000209 Zobrazit plný text záznamu