Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Autor:	Luke B Snell, Adela Alcolea-Medina, Themoula Charalampous, Christopher Alder, Tom G S Williams, Flavia Flaviani, Rahul Batra, Prijay Bakrania, Rajeni Thangarajah, Stuart J D Neil, Claire van Nispen tot Pannerden, Alina Botgros, Emma Aarons, Samuel T Douthwaite, Jonathan D Edgeworth, Gaia Nebbia
Rok vydání:	2022
Předmět:	Microbiology (medical) Infectious Diseases
Zdroj:	Clinical Infectious Diseases. 76:1125-1128
ISSN:	1537-6591 1058-4838
Popis:	The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::168e85568bc8f3b320c51b672c2f1dc4 https://doi.org/10.1093/cid/ciac864 Zobrazit plný text záznamu