Neural cell adhesion molecule expression in dilated cardiomyopathy is associated with intramyocardial inflammation and hypertrophy
| Autor: | Michel Noutsias, Heinz-Peter Schultheiss, Karsten Ostermann |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty ICAM-1 business.industry Cell adhesion molecule Cardiomyopathy Cardiac muscle Dilated cardiomyopathy 030204 cardiovascular system & hematology medicine.disease Muscle hypertrophy Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure nervous system Medicine Neural cell adhesion molecule Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Cardiology. 241:322-325 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2017.03.072 |
| Popis: | Chronic intramyocardial inflammation (inflammatory cardiomyopathy/DCMi) is linked to the pathogenesis of dilated cardiomyopathy (DCM). Neural cell adhesion molecule (NCAM) is involved in orchestrating cardiac muscle morphogenesis, but is down-regulated after embryogenesis. We investigated NCAM expression in adult DCM hearts, its possible association with DCMi-parameters, and with cardiomyocyte hypertrophy (CMH). Endomyocardial biopsies (EMBs) from DCM patients (n=85; n=37 females; age: 48±19years; LVEF |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect