Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura
| Autor: | Mushtaq Wani, Sebastian Brandner, Gargi Banerjee, Henry Houlden, Zane Jaunmuktane, Matthew Adams, G. Alistair Lammie, Inder Sawhney, Ben Turner, David J. Werring, Simon Mead |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Magnetic resonance imaging medicine.disease Hemangioma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neurology Neuroimaging mental disorders medicine Neurology (clinical) Cerebral amyloid angiopathy Embolization Age of onset business Cadaveric spasm 030217 neurology & neurosurgery Craniotomy |
| Zdroj: | Annals of Neurology. 85:284-290 |
| ISSN: | 0364-5134 |
| Popis: | Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1-7 ANN NEUROL 2019;85:284-290. |
| Databáze: | OpenAIRE |
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