Synthesis of Some Pyrazolo[3, 4]pyrimidine Derivatives for Biological Evaluation

Autor:	Aymn E. Rashad, H. H. Sayed, Ahmed H. Shamroukh
Rok vydání:	2005
Předmět:	Inorganic Chemistry Turn (biochemistry) chemistry.chemical_compound Pyrimidine chemistry Derivative (finance) Organic Chemistry Pyrazole Antimicrobial Biochemistry Combinatorial chemistry Biological evaluation
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 180:2347-2360
ISSN:	1563-5325 1042-6507
DOI:	10.1080/104265090921074
Popis:	A novel β -enaminonitrile of 1-(6-p-tolyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-p-tolyl-pyridazin-3-yl)-hydrazine ( 1 ) and 2-ethoxymethylenemalononitrile. The β-enaminonitrile derivative 2 was in turn used as a precursor for the preparation of pyrazoles ( 4 , 6 ), pyrazolo[3, 4-d]-pyrimidines ( 3 , 7–12 ) and pyrazolo[4, 3-e][1,2,4]triazolo[4,3-c]pyrimidine ( 13 ). Also, N- and S-acyclic nucleosides 14 and 15 were prepared. Some of the prepared products showed potent antimicrobial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::16835e13c80bcabe51abc3f2a6068ee1 https://doi.org/10.1080/104265090921074 Zobrazit plný text záznamu