New route to enantiomerically pure 4,4-Disubstituted cyclohex-2-en-1-ones: Asymmetric synthesis of (+)-mesembrine

Autor:	Hiroshi Kosugi, Hisashi Uda, Yasuyuki Miura, Hiroshi Kanna
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Ketone Intramolecular reaction Organic Chemistry Acetal Enantioselective synthesis Sulfoxide Catalysis Cycloaddition Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Enone Mesembrine
Zdroj:	Tetrahedron: Asymmetry. 4:1409-1412
ISSN:	0957-4166
Popis:	Enantiomerically pure β,β-disubstituted vinyl sulfoxides undergo cycloaddition with dichloroketene to give β,β-disubstituted γ-lactones which are transformed into synthetically important 44-disubstituted cyclohex-2-enones in optically pure form. The present method is applied to the synthesis of enantiomerically pure (+)-mesembrine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::168313b57ad1dc5917ec2ced3d5b94cc https://doi.org/10.1016/s0957-4166(00)80327-4 Zobrazit plný text záznamu