| Popis: |
When a drug is given orally, the proportion of the administered dose which reaches the systemic circulation varies widely, depending on the drug and the conditions of its use. Measurement of this proportion, and the rate f(t) at which the drug reaches the circulation, is an important part of drug development. The reconstruction of f(t) is an inference problem with sparse and noisy data. Estimates of f(t), the total amount of drug reaching the bloodstream, and other quantities of interest may be obtained, together with their uncertainties, using a Bayesian analysis in which entropy appears naturally in the prior probability. |
