Increased thymic development of regulatory T cells in NOD mice is functionally dissociated from type I diabetes susceptibility

Autor:	Rita Vicente, Paola Romagnoli, Joost P. M. van Meerwijk, Nicolas Thiault, Andry Andrianjaka, Julie Tellier, Geneviève Enault, Henri-Jean Garchon
Rok vydání:	2013
Předmět:	biology Immunology Congenic chemical and pharmacologic phenomena Locus (genetics) Nod medicine.disease Major histocompatibility complex Chromosome 17 (human) Diabetes mellitus medicine biology.protein Immunology and Allergy Gene NOD mice
Zdroj:	European Journal of Immunology. 43:1356-1362
ISSN:	0014-2980
DOI:	10.1002/eji.201243142
Popis:	Regulatory T (Treg) lymphocytes play a central role in the control of autoimmune pathology. Any alteration in Treg-cell biology in mouse strains used for the study of these disorders therefore raises the question of its direct link with disease susceptibility. Paradoxically, in non-obese diabetic (NOD) mice increased numbers of Treg cells develop in the thymus. In this report we identify a locus of
Databáze:	OpenAIRE
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