The Electron Donor–Acceptor Interaction between Mixed Solvents and Its Influence on Their β-Sheet Structure-Disrupting Potential
| Autor: | Mitsuaki Narita, Chie Sasaki, Hiroshi Umeyama, Shizuko Isokawa, Shinya Honda, Hideaki Kakei |
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| Rok vydání: | 1989 |
| Předmět: | |
| Zdroj: | Bulletin of the Chemical Society of Japan. 62:780-785 |
| ISSN: | 1348-0634 0009-2673 |
| DOI: | 10.1246/bcsj.62.780 |
| Popis: | Cross-linked polystyrene resin-bound peptides were useful for the investigation of the β-sheet structure-disrupting potential of mixed solvents although their β-sheet structure-disrupted behavior by mixed solvents was different from that of peptides free from a macromolecular protecting group due to the concentrating efficacy of a cross-linked resin. In mixed solvents, the electron-acceptor and -donor numbers (AN and DN) of organic solvents were one of the most important factors to estimate their β-sheet structure-disrupting potential. In a mixture of electron-acceptor solvents themselves or -donor solvents, the electron donor-acceptor interaction between solvents did not occur and electron-accepting or -donating property of each solvent was kept to disrupt the β-sheet aggregation in mixed solvents. On the other hand, in a mixture of electron-acceptor solvent and -donor solvent, the electron donor-acceptor interaction between solvents occurred predominantly to decrease the β-sheet structure-disrupting pot... |
| Databáze: | OpenAIRE |
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