| Popis: |
Sir, The entity now known as acute infantile haemorrhagic oedema (AIHO) of the skin was ® rst described by Snow (1) in 1913. This disease primarily affects infants younger than 24 months of age, and is characterized by low-grade fever, sudden-onset purpura (often in a cockade pattern) and in ammatory oedema of the limbs and face. The most striking feature of AIHO is the contrast of these dramatic cutaneous signs in a patient who is otherwise in good general condition. In most cases of AIHO, the disease is con® ned to the skin with no visceral involvement. The course of the disease is short and benign, and patients show complete spontaneous recovery (2 ± 6). The aetiopathogenesis of AIHO is not well understood, but bacterial (3 ± 5, 8) or viral infection (3, 4, 10), vaccination (3, 4) and drug intake (3, 4, 7 ± 9) have all been proposed as causes. The authors of previous case reports agree that AIHO should be classi® ed within the spectrum of leucocytoclastic vasculitis (3 ± 9, 11, 12); however, the histopathological ® ndings do not always meet the criteria for leucocytoclastic vasculitis (4). Here, we report an infant with AIHO that may have been triggered by measles vaccination. The histopathologic criteria for leucocytoclastic vasculitis were absent in this case. To our knowledge, this is the ® rst report of AIHO occurring after measles vaccination. |
