Mitochondria-targeted dual-channel colorimetric and fluorescence chemosensor for detection of Sn2+ ions in aqueous solution based on aggregation-induced emission and its bioimaging applications
| Autor: | Prakash Ramalingam, Ponmalai Kolandaivel, Maciej Masłyk, Ae Rhan Kim, Byung-Hyun Park, Palanisamy Ravichandiran, Nikhil Maroli, Myung-Kwan Han, Thiyagarajan Ramesh, Anna Boguszewska-Czubara, D.S. Prabakaran, Dong Jin Yoo |
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| Rok vydání: | 2021 |
| Předmět: |
021110 strategic
defence & security studies Environmental Engineering Aqueous solution Health Toxicology and Mutagenesis Metal ions in aqueous solution 0211 other engineering and technologies Colocalization 02 engineering and technology 010501 environmental sciences 01 natural sciences Pollution Combinatorial chemistry Fluorescence Naphthoquinone Quinone chemistry.chemical_compound chemistry Environmental Chemistry Moiety Selectivity Waste Management and Disposal 0105 earth and related environmental sciences |
| Zdroj: | Journal of Hazardous Materials. 415:125593 |
| ISSN: | 0304-3894 |
| Popis: | Several fluorescence and colorimetric chemosensory for Sn2+ detection in an aqueous media have been reported, but applications remain limited for discriminative Sn2+ detection in live human cells and zebrafish larvae. Herein, a mitochondria-targeted Sn2+ “turn-on” colorimetric and fluorescence chemosensor, 2CTA, with an aggregation-induced emission (AIE) response was developed. The sensing of Sn2+ was enabled by a reduction-enabled binding pathway, with the conversion of –C˭O groups to –C–OH groups at the naphthoquinone moiety. The color changed from light maroon to milky white in a buffered aqueous solution. The chemosensor 2CTA possessed the excellent characteristics of good water solubility, fast response (less than 10 s), and high sensitivity (79 nM) and selectivity for Sn2+ over other metal ions, amino acids, and peptides. The proposed binding mechanism was experimentally verified by means of FT-IR and NMR studies. The chemosensor 2CTA was successfully employed to recognize Sn2+ in live human cells and in zebrafish larvae. In addition, a colocalization study proved that the chemosensor had the ability to target mitochondria and overlapped almost completely with MitoTracker Red. Furthermore, a bioimaging study of live cells demonstrated the discriminative detection of Sn2+ in human cancer cells and the practical applications of 2CTA in biological systems. |
| Databáze: | OpenAIRE |
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