Leonotis nepetifolia Protects against Acetaminophen-Induced Hepatotoxicity: Histological Studies and the Role of Antioxidant Enzymes
| Autor: | Arlene F Williams, Y Clement, Rao Avc, Nayak Sb |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Liver injury
Antioxidant 020205 medical informatics biology Chemistry medicine.medical_treatment digestive oral and skin physiology 02 engineering and technology Pharmacology Leonotis nepetifolia biology.organism_classification medicine.disease_cause medicine.disease Enzyme assay Acetaminophen 03 medical and health sciences 0302 clinical medicine Catalase 0202 electrical engineering electronic engineering information engineering medicine biology.protein 030212 general & internal medicine Antidote Oxidative stress medicine.drug |
| Zdroj: | Natural Products Chemistry & Research. |
| ISSN: | 2329-6836 |
| DOI: | 10.4172/2329-6836.1000222 |
| Popis: | Aim of the study: High dose acetaminophen (APAP) increases the risk of liver injury caused by oxidative stress due to accumulation of reactive species. Although N-acetyl cysteine is the standard antidote used to treat acute APAPinduced liver failure, we proposed that known antioxidant phytochemicals in Leonotis nepetifolia extracts would protect against APAP-induced hepatic injury by modulating the activities of antioxidant enzymes. Materials and methods: Methanol and aqueous extracts of L. nepetifolia were orally administered in doses ranging (250 mg/kg to 1000 mg/kg) as pre- and post-treatment with high dose APAP (550 mg/kg) to Swiss albino mice. Twenty-four hours after the final dose, animals were euthanized and blood and liver collected for liver enzymes (ALT and AST), histological assessment and antioxidant enzyme assays. Results: Methanol and aqueous extracts as pre-treatment and post-treatment protected against hepatic injury. Extracts abrogated the 14-fold and 4-fold APAP-induced increases in ALT and AST respectively, including histopathological damage (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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