Selenoprotein T: From Discovery to Functional Studies Using Conditional Knockout Mice
| Autor: | Isabelle Lihrmann, Gaëtan Prévost, Ifat Alsharif, Youssef Anouar, Loubna Boukhzar, Dorthe Cartier, Abdeslam Chagraoui, Houssni Abid, Abdallah Hamieh, Matthieu T. Castex, Yannick Tanguy, Anthony Falluel-Morel |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology Endoplasmic reticulum Neurodegeneration Selenoprotein T Biology medicine.disease Cell biology 03 medical and health sciences 030104 developmental biology Conditional gene knockout Knockout mouse medicine Endocrine system Homeostasis Hormone |
| Zdroj: | Selenium ISBN: 9783319412818 |
| DOI: | 10.1007/978-3-319-41283-2_23 |
| Popis: | Selenoprotein T (SELT) is a thioredoxin-like enzyme that exerts an essential oxidoreductase activity in the endoplasmic reticulum during development and after tissue injury where its expression is highly induced. Disruption of the Selt gene is lethal during embryogenesis, and its conditional knockout in the brain causes the reduction of several cerebral structures and increases the vulnerability of mice to neurotoxin-induced neurodegeneration. While its expression is silenced in most tissues in the adult, SELT persists at high levels in endocrine tissues such as the pancreas where it controls hormone production. Thus, SELT could be involved in the redox circuits that control homeostasis and survival of cells with intense metabolic activity during development or in adult endocrine and lesioned cerebral tissues. |
| Databáze: | OpenAIRE |
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