Localization of the human glucagon gene (GCG) to chromosome segment 2q36→37

Autor:	W.T. Schroeder, L.C. Lopez, G.F. Saunders, M.E. Harper
Rok vydání:	1984
Předmět:	Nucleic acid thermodynamics Plasmid Complementary DNA Genetics Chromosome Biology Molecular Biology Gene Glucagon Metaphase Molecular biology Chromosome 22 Genetics (clinical)
Zdroj:	Cytogenetic and Genome Research. 38:76-79
ISSN:	1424-859X 1424-8581
DOI:	10.1159/000132034
Popis:	Hybridization of a 3H-labeled bovine glucagon cDNA plasmid to human metaphase chromosomes revealed significant labeling of the distal portion of the long arm of chromosome 2. A large portion (37%) of the cells analyzed exhibited labeling of the 2. A significant percentage (40%) of the labeled sites on the 2 were in segment 2q36→37. Therefore, the human glucagon gene (GCG), was assigned to this segment. Localization of the glucagon gene, whose chromosomal assignment was previously not known, demonstrates the general applicability of in situ hybridization as a powerful gene mapping technique.
Databáze:	OpenAIRE
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