Nasale Applikation eines synthetischen α1–18-Corticotropins

Autor:	Geyer G, Templ H
Rok vydání:	1976
Předmět:	business.industry Nostril Therapeutic effect Acth treatment Injection therapy Mucous membrane of nose General Medicine Absorption (skin) respiratory system medicine.disease medicine.anatomical_structure Anesthesia Rheumatoid arthritis medicine business Asthma
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 101:1806-1808
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-0028-1104343
Popis:	The absorption of a synthetic ACTH-peptide (alpha1-18 corticotropin, Ba 41.795) via the nasal mucosa was investigated in twelve probands. After application of 1 mg into each nostril a rapid increase of the plasma cortisol was observed which returned to the initial value only after 7 hours. In two patients with rheumatoid arthritis and two patients with bronchial asthma who had been treated with regular steroid injections an attempt was made to replace the injections by nasal application. The same therapeutic effects could be obtained, but larger doses were required than when using injection therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::164f8a1c155041a67413d379d52fffa5 https://doi.org/10.1055/s-0028-1104343 Zobrazit plný text záznamu