Formulation Development of Canine Antifungal Shampoo Containing Senna tora (L.) Roxb. Seed Extract
| Autor: | Suchada Jongrungruangchok, Duangdeun Meksuriyen, Natawat Chankana, Laksana Charoenchai, Vimolmas Lipipun, Orawan Theanphong |
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| Rok vydání: | 2020 |
| Předmět: |
010302 applied physics
Antifungal Senna tora biology Traditional medicine medicine.drug_class Mechanical Engineering 02 engineering and technology 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Shampoo chemistry.chemical_compound chemistry Mechanics of Materials 0103 physical sciences Anthraquinones medicine General Materials Science Microsporum canis 0210 nano-technology |
| Zdroj: | Key Engineering Materials. 859:181-187 |
| ISSN: | 1662-9795 |
| Popis: | This research aims to develop canine shampoo containing Senna tora seed extract. The crude ethanolic extract was partial purified through column chromatography. The extract and shampoo formulation were identified for four main anthraquinones i.e. aloe-emodin, emodin, chrysophanol and physcion using a RP-HPLC. Formulation development was evaluated for compositions, physical properties, and antifungal activity against Microsporum canis. Our results indicated that sodium lauryl ether sulfate (20%) was an appropriate detergent with cocamidopropyl betain (4-6%) as a foam booster. Polyethylene glycol-120 methylglucose (2-3%) was a thickening agent and propylene glycol (6-7%) was a co-solvent and humectant. This shampoo showed relatively potent antifungal activity against M. canis compared with 2% ketoconazole commercial shampoo (%inhibition 75.27 and 85.85, respectively). The formulation was clear, dark brown liquid with delicate and stable foam, including effective cleaning action. Although this shampoo showed decrease in pH and viscosity after heating and cooling acceleration test, it was still effective as antifungal against M. canis with %inhibition of 69.10. Further long term stability study and some optimizations are still needed. |
| Databáze: | OpenAIRE |
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