Synthesis of a water-soluble chiral NMR shift reagent: (S)-PDTA

Autor:	Claudia Zucchi, Nicola Florini, Gyula Pályi, Bálint Kónya, Gaelle Francoise Arnaud
Rok vydání:	2009
Předmět:	Alanine Denticity Chemistry Stereochemistry Ligand Organic Chemistry Medicinal chemistry Catalysis Inorganic Chemistry Water soluble Yield (chemistry) Reagent Physical and Theoretical Chemistry Chirality (chemistry)
Zdroj:	Tetrahedron: Asymmetry. 20:1036-1039
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2009.02.063
Popis:	A five-step synthesis of the water-soluble chiral polydentate ligand, ( S )-PDTA [( S )-PDTA = N , N , N ′, N ′-tetrakis[(hydroxycarbonyl)methyl]-( S )-1,2-diaminopropane] starting from l -alanine has been worked out, via steps with retention of chirality. Total yield is 50.7% (average of ∼88% for each step), while published methods report 33.4% total yield over four steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::163160637b360a692d83a307b999e1ea https://doi.org/10.1016/j.tetasy.2009.02.063 Zobrazit plný text záznamu Full Text from ScienceDirect