| Popis: |
AIM: To examine whether ventilation-carbon dioxide output indices(ΔVE/ΔVCO2 slope) and ventilation–oxygen output indices (ΔVE/ΔVO2 slope) and oxygen uptake (ΔVO2/ΔWR)slopes differ among patients with cystic fibrosis (CF) lung disease. To investigate if these slopes are related to structural lung damages, spirometry findings and ventilation inhomogeneity. METHODS: CF patients with mild (FEV1%>80%, n=47), moderate (60% RESULTS: Mean ΔVE/ΔVCO2 for the mild disease group was 29.9, for the moderate 29.4 and for severe disease group 27.1 with no significant differences reported between the groups (p: 0.503). However, VE together with ΔVE/ΔVCO2 slope showed a significant correlation with Bhalla score (r2=0.869, p=0.006) and ΔVO2/ΔWR slope correlated significantly with Bhalla score (r2=0.197, p=0.038) in the total population. VE plus VO2min could predict LCI (r2=0.319, p CONCLUSION: Exercise testing slopes can reflect structural lung damages in CF youths regardless disease severity. Exercise testing can provide crucial information not only on the patients9 exercise capacity, but also on commencing lung damages. |
