Munching microbes: diet–microbiome interactions shape gut health and cancer outcomes
| Autor: | Miguel Castaneda, Reem Elnour, Emma Todd, Erin R. Shanahan, Rebecca Simpson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Gastrointestinal tract Public Health Environmental and Occupational Health Cancer Biology Intestinal mucin medicine.disease Applied Microbiology and Biotechnology Microbiology Treatment efficacy Cancer treatment 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Increased risk 030220 oncology & carcinogenesis medicine Microbiome Digestion |
| Zdroj: | Microbiology Australia. 42:60-64 |
| ISSN: | 2201-9189 1324-4272 |
| DOI: | 10.1071/ma21026 |
| Popis: | The gut microbiome describes the complex community of microorganisms that populate the gastrointestinal tract. Gut microbes in the large bowel utilise both dietary-derived nutrients, such as host-indigestible carbohydrates (fibre) and excess protein, host-derived nutrients (intestinal mucin), and also interact with the by-products of digestion such as bile acids. They transform these compounds into a series of metabolites that can profoundly shape host physiology both locally and systemically. These metabolites can fundamentally alter host outcomes, promoting either gut health, or sub-optimal conditions in the gut that contribute to poor health, including increased risk of cancer. The microbiome of an individual has also been shown to impact response to cancer treatment strategies, including both treatment efficacy and side-effects in the gut and more systemically. This makes the microbiome a powerful potential tool for therapeutic purposes, once we overcome the challenges associated with individual variation in microbial community composition. As the gut microbial ecosystem is primarily altered by nutrient availability, diet therefore represents an important asset in therapeutically altering the gut microbiome. |
| Databáze: | OpenAIRE |
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