C24 MICROALBUMINURIA DURING ACUTE CORONARY AS LONG–TERM PROGNOSTIC FACTOR. RESULTS FROM 24 YEARS OF FOLLOW–UP OF THE ABC–9 STUDY ON HEART DISEASE
| Autor: | G Berton, R Cordiano, R Palmieri, F Cavuto, M Mohammed Ahmed, F Bagato, D Merotto, F Menegon, P Palatini, H Mahmoud |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Heart Journal Supplements. 25:D10-D11 |
| ISSN: | 1554-2815 1520-765X |
| DOI: | 10.1093/eurheartjsupp/suad111.023 |
| Popis: | Background Microalbuminuria is one of the earliest biomarkers of kidney injury that reflects an endothelial dysfunction with increased glomerular permeability and it is independently associated with adverse outcomes in several clinical situations. Methods To evaluate the very long–term prognostic yield of baseline microalbuminuria in patients with acute coronary syndrome (ACS), we prospectively studied 589 ACS patients admitted to three Italian hospitals. The baseline albumin/creatinine ratio (ACR) was measured on days 1, 3, and 7 in 24–h urine samples. Patients were followed for 24 years or until death. Results Virtually all patients completed the follow–up, representing 7066 person–years. During follow–up, 482(82%) had died: 38% due to non–sudden cardiac death (non–SCD), 19% sudden cardiac death (SCD), and 43% due to non–cardiac (non–CD) death. Throughout the 1st admission week, ACR was consistently higher in the patients who died during follow–up than in those who survived. Similar higher values were found for deaths from non–SCD causes. The unadjusted Cox regression analysis revealed that ACR is a significant predictor of all–cause mortality (HR:1.24; 95%CI 1.20–1.28; p Conclusion This prospective study shows that baseline ACR during ACS seems to be a strong independent long–term risk predictor, chiefly associated with non–sudden cardiac death. Positive independent interaction with indicators of heart failure has been also observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|