Acute effects of atrial natriuretic peptide on left ventricular diastolic function

Autor:	C Macleod, NM Wheeldon, Thomas M. MacDonald, Wendy J. Coutie, Pbm Clarkson
Rok vydání:	1995
Předmět:	medicine.medical_specialty business.industry Diastole medicine.disease Placebo Blood pressure Atrial natriuretic peptide Internal medicine Circulatory system Heart rate medicine Cardiology Cardiology and Cardiovascular Medicine business Isovolumic relaxation time Stroke
Zdroj:	European Heart Journal. 16:1710-1715
ISSN:	1522-9645 0195-668X
DOI:	10.1093/oxfordjournals.eurheartj.a060799
Popis:	Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of atrial natriuretic peptide (0.5, 1, 2, 5 pmol.kg-1.min-1) and placebo (0.9% (w/v) saline) in ten normal male subjects. Compared with placebo, atrial natriuretic peptide infusion produced a significant and dose-related reduction in the isovolumic relaxation time [(mean and 95% CI) -5.9 (-9.2 to -2.6) ms (P < 0.01) at 5 pg.kg-1 min-1] and a significant increase in the ratio between early and late transmitral peak velocities [0.46 (0.02 to 0.89) (P < 0.05) at 5 pg.kg-1 min-1]. No significant changes in heart rate, blood pressure or aortic stroke distance were observed with infusion of atrial natriuretic peptide compared with placebo. These data suggest that pathophysiological plasma concentrations of atrial natriuretic peptide improve diastolic function by increasing the rate of myocardial relaxation.
Databáze:	OpenAIRE
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