Synthesis and Antioxidant Activity of Ammonium Salts of 4-(3-Bromophenyl)-5-Methoxycarbonyl-1-(N,N-Dimethylaminopropyl)-3,4-Dihydropyrimidin-2-(1H)-One

Autor:	Oleg Kushnir, Mykhailo Vovk, Mykhailo Marchenko, Oksana Voloshchuk
Rok vydání:	2015
Předmět:	Pharmacology Acrylate Antioxidant Hydrochloride medicine.medical_treatment Pharmacology toxicology Alkylation Mass spectrometry Medicinal chemistry chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry Ammonium
Zdroj:	Pharmaceutical Chemistry Journal. 49:515-518
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-015-1318-5
Popis:	Methyl-3-{[2-(dimethylamino)propyl]amino}acrylate reacted with α-chloro-3-bromobenzylisocyanate to synthesize 4-(3-bromophenyl)-5-methoxycarbonyl-1-(N,N-dimethylaminopropyl)-3,4-dihydropyrimidin-2(1H)-one hydrochloride, alkylation of which by chloroacetate esters yielded a series of quaternary ammonium salts. The structures of the compounds were confirmed by IR and PMR spectroscopy and mass spectrometry. Some of the synthesized compounds exhibited high inhibitory activity with respect to the superoxide-generating ability of mitochondria in both the liver and transformed tissue of tumor-bearing rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::162564331aecc7649de35ec6d1689902 https://doi.org/10.1007/s11094-015-1318-5 Zobrazit plný text záznamu Plný text ve formátu PDF