N-Nitrosamines – Method for the determination of N-nitrosamines in workplace air using gas chromatography with a thermal energy analyzer (GC-TEA) after elution

Autor: Giesen, Yvonne, Werner, Silke, Brock, Thomas Helmut, Hebisch, Ralph, Hartwig, Andrea, MAK Commission
Jazyk: angličtina
Rok vydání: 2022
Předmět:
gas chromatography
ThermoSorb-N cartridge
NDPA
Messbereich
Ethylmethylnitrosamin
Luftanalysen
NMEA
hazardous substance
N-Nitrosoethylmethylamin
N-Methyl-N-nitrosomethanamin
Wiederfindung
Methode 05
Diethylnitrosamin
ThermoSorb-N-Kartusche
air analyses
N-Nitrosodi-n-butylamin
NDMA
Präzision
workplace measurement
analytical method
Selektivität
Dipropylnitrosamin
DGUV Information 213-523
Gefahrstoff
Bestimmungsgrenze
method 05
N-Nitrosomethylethylamin
Gaschromatographie
N-Nitrosodibutylamin
sampling
measurement range
NPIP
DiPNA
NDBA
N-Nitrosodimethylamin
GC-TEA
4-Nitrosomorpholin
recovery
Dimethylnitrosoamin
NPYR
N-nitrosamines
German Social Accident Insurance
DMN
N-Nitrosodiethylamin
N-Nitrosodiisopropylamin
DGUV
Arbeitsplatzmessung
NMOR
N-Nitrosopiperidin
N-Nitrosopyrrolidin
N-Nitrosodi-n-propylamin
Deutsche Gesetzliche Unfallversicherung
NEMA
NDiPA
Probenahme
N-Nitrosomorpholin
selectivity
DnPNA
1-Nitrosopyrrolidin
Analysenmethode
Diisopropyl-N-nitrosamin
DMNA
AG Analytik
working group analytics
precision
N
N-Dimethylnitrosamin
N-Nitrosamine
limit of quantification
Dibutylnitrosamin
N-Nitrosotetrahydro-1
4-oxazin
DOI: 10.34865/am6275e7_2or
Popis: This analytical method is a validated measurement procedure for the determination of 9 N-nitrosamines such as N-nitrosodimethylamine [62-75-962-75-9], N-nitrosomethylethylamine [10595-95-610595-95-6], N-nitrosodiethylamine [55-18-555-18-5], N-nitrosodiisopropylamine [601-77-4601-77-4], N-nitrosodi-n-propylamine [621-64-7621-64-7], N-nitrosodi-n-butylamine [924-16-3924-16-3], N-nitrosopiperidine [100-75-4100-75-4], N-nitrosopyrrolidine [930-55-2930-55-2], N-nitrosomorpholine [59-89-259-89-2] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a ThermoSorb-N cartridge using a suitable flow-regulated pump. Afterwards the cartridges are eluted with dichloromethane/methanol (3:1, v:v) and the sample solution is analysed by means of gas chromatography with a thermal energy analyser (TEA) detector. The relative limit of quantification (LOQ) is 0.010 µg/m3 N-nitrosamine per cartridge for an air sample volume of 400 l. The mean recovery for all nine N-nitrosamines was between 96% and 102% and the expanded uncertainty for the analysed N-nitrosamines was between 19% and 27% over the entire measurement range. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction.This method has been tested and recommended for the determination of N-nitrosamines in work areas by the German Social Accident Insurance (DGUV).Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.
Databáze: OpenAIRE
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