| Popis: |
Mice received during a three-day period oral pentylenetetrazol, reserpine, and niacin singly or in combination prior to challenge with oral pentylenetetrazol. Niacin (20 mg./Kg./day) and pentylenetetrazol (50 mg./Kg./day) did not significantly influence the challenge CD 50 and TD 50 . Reserpine (8 mg./Kg./day) induced an apparent lowering of CD 50 and a significant decrease in TD 50 ; dietary limitation led to similar results. The administration of a mixture containing the above concentrations of pentylenetetrazol and niacin, and reserpine 0.5 mg./Kg./day did not significantly affect the subsequent challenge CD 50 and TD 50 . |
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