Controlling biofilm formation with nitroxide functional surfaces
| Autor: | Robert E. W. Hancock, Kathryn E. Fairfull-Smith, Christopher Barner-Kowollik, Leonie Barner, Vanessa Trouillet, Alexander Welle, Daniel Pletzer, Michael J. Trimble, Hendrik Woehlk, Sarah C. Mansour |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Nitroxide mediated radical polymerization Polymers and Plastics Organic Chemistry Biofilm Bioengineering Nanotechnology 02 engineering and technology Polymer engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial 01 natural sciences Biochemistry 0104 chemical sciences chemistry Coating engineering Adhesive 0210 nano-technology Healthcare system |
| Zdroj: | Polymer Chemistry. 10:4252-4258 |
| ISSN: | 1759-9962 1759-9954 |
| Popis: | Bacterial biofilm formation on medical devices is a threat to healthcare systems worldwide as bacteria within a biofilm are more resistant to standard antimicrobial therapies. Herein, we introduce a nitroxide-based antibiofilm coating strategy, which is specifically designed to prevent biofilm formation of Gram-negative pathogens such as Pseudomonas aeruginosa. Nitroxide-decorated hydroxyapatite surfaces were readily prepared in an aqueous dip-coating procedure using a nitroxide-functionalized catecholamine as a polymerizable coating agent. Additional spatial control over the polymer surface deposition on titanium was gained by applying a photolithographic coating setup. All nitroxide-coated surfaces exhibited excellent antibiofilm properties toward PA14 surface colonization as biofilm formation was completely suppressed. Importantly, the surrounding adhesive polymer matrix did not interfere with the nitroxide-characteristic antibiofilm properties. The herein introduced platform technology represents a bioinspired and versatile coating approach, offering a safe and prophylactic avenue to combat biofilm contamination on a variety of surfaces. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|