Treatment of tinea capitis - griseofulvin versus fluconazole - a comparative study

Autor:	Ira Bernstein Plotnik, Batya Davidovici, Marcelo H. Grunwald, Boaz Amichai, Avner Shemer, Ronen Magun
Rok vydání:	2013
Předmět:	medicine.medical_specialty business.industry Treatment duration Significant difference Dermatology Griseofulvin medicine.disease chemistry.chemical_compound chemistry Tolerability medicine Tinea capitis business Fluconazole medicine.drug
Zdroj:	JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 11:737-741
ISSN:	1610-0379
Popis:	Summary Objective To compare the efficacy and safety of fluconazole and griseofulvin in the treatment of tinea capitis. Patients and Methods Patients with tinea capitis (n = 113) with positive fungal cultures entered the study. The patients were divided into four groups with different treatment regimes. Two groups received griseofulvin 15 or 25 mg/kg/day and two groups received fluconazole 4 or 6 mg/kg/day, all for up to 12 weeks. Results Griseofulvin was found to be slightly better than fluconazole. The lower doses for both griseofulvin and fluconazole required significantly longer treatment duration until mycological cure than the higher doses, independent of the fungus type. Conclusions Since no significant difference was found between the drugs, it is suggested that the choice should be based on tolerability, availability and cost of the drugs.
Databáze:	OpenAIRE
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