Use of lanthanum to detect changes in the permeability barrier of rat skin after dermal exposure to organic chemicals
| Autor: | D.R. Mattie, C.J. Hixson, M.R. Chase, J.N. McDougal |
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| Rok vydání: | 1987 |
| Předmět: |
Materials science
integumentary system Trichloroethylene medicine.medical_treatment General Medicine Penetration (firestop) Environmental exposure Toxicology chemistry.chemical_compound Coagulative necrosis medicine.anatomical_structure Dermis chemistry Toxicity medicine Stratum corneum Biophysics Saline |
| Zdroj: | Proceedings, annual meeting, Electron Microscopy Society of America. 45:870-871 |
| ISSN: | 2690-1315 0424-8201 |
| DOI: | 10.1017/s0424820100128638 |
| Popis: | Occupational dermal exposures to organic solvents are of importance due to local effects in the skin and systemic toxicity if penetration occurs through the skin. Repeated or prolonged contact with organic solvents may cause dry skin and cutaneous irritation. Although organic solvents have been shown to penetrate the skin, little information is available concerning the effects on the barrier properties of skin after dermal exposure to solvents. The purpose of this investigation was to examine the ultra- structural changes in rat skin after exposure to 3 organic chemicals and to correlate changes with the location of an electron dense tracer, lanthanum, which is normally excluded by the permeability barrier in the stratum corneum.Male rats, 6 for saline and 6 for each chemical, were exposed for 24 h to sterile saline, trichloroethylene (TCE), perchloroethylene (PERC), or toluene using dermal exposure cells developed in this laboratory. The cells were filled with 2 mL of saline or the neat chemical. |
| Databáze: | OpenAIRE |
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