Extraction of medicinal compounds of the benzodiazepines class from aqueous solutions and their following gas chromatographic determination
| Autor: | S. M. Leshchev, O. N. Mikhniuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Chloroform Chromatography Aqueous solution 010405 organic chemistry Organic Chemistry Distribution constant Extraction (chemistry) Salt (chemistry) 010402 general chemistry 01 natural sciences 0104 chemical sciences Analytical Chemistry Inorganic Chemistry Matrix (chemical analysis) Potassium carbonate chemistry.chemical_compound chemistry Chemistry (miscellaneous) Salting out |
| Zdroj: | Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 57:177-184 |
| ISSN: | 2524-2342 1561-8331 |
| Popis: | In extraction systems hexane–water, hexane–aqueous solutions of inorganic salts (sodium chloride, dipotassium phosphate and potassium carbonate), chloroform–water using the method of gas chromatography–mass spectrometry, the distribution constants of psychotropic substances, limited to movement through the customs border of the Republic of Belarus – alprazolam, lorazepam, temazepam, and as well as clozapine, a medicinal product permitted for movement, were determined. The greatest dynamics of the growth of the distribution constant versus salt concentration was observed in alprazolam. It was found that replacing hexane with chloroform leads to increasing the distribution constants and the quantitative extraction of all substances. However, for the selective extraction of substances from various objects and the simultaneous removal of matrix components, it is necessary to use the systems as hexane–aqueous solutions of salts or hexane–water. Based on the obtained values of the distribution constants of substances, extraction-chromatographic technique for the determination of organic nonelectrolytes (benzodiazepines) in various objects is proposed. Metrological characteristics of the techniques are: relative standard deviation does not exceed 2 %, the range of determined concentrations in solutions is 0,05– 1,00 g/dm3. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|