Abnormal production of the tumor necrosis factor inhibitor etanercept and clinical efficacy of tumor in a patient with PAPA syndrome
| Autor: | Elisabetta Cortis, Fabrizio De Benedetti, Antonella Insalaco, Stefania Cioschi, Alberto G. Ugazio, L E D'Urbano, Flaminia Muratori |
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| Rok vydání: | 2004 |
| Předmět: |
Proband
medicine.medical_specialty business.industry medicine.medical_treatment PAPA syndrome medicine.disease Peripheral blood mononuclear cell Gastroenterology Etanercept Cytokine Internal medicine Pediatrics Perinatology and Child Health Immunology Sterile arthritis medicine Tumor necrosis factor alpha business Acne medicine.drug |
| Zdroj: | The Journal of Pediatrics. 145:851-855 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2004.08.001 |
| Popis: | We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-α by mononuclear cells of the proband and of the affected relatives was abnormally elevated. |
| Databáze: | OpenAIRE |
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