Longitudinal association of hypertension and dyslipidemia with cognitive function in community-dwelling older adults: the SONIC study

Autor: Yuko Nakamura, Mai Kabayama, Kayo Godai, Winston Tseng, Hiroshi Akasaka, Koichi Yamamoto, Yoichi Takami, Yasushi Takeya, Yasuyuki Gondo, Saori Yasumoto, Madoka Ogawa, Ayaka Kasuga, Yukie Masui, Kazunori Ikebe, Yasumichi Arai, Tatsuro Ishizaki, Hiromi Rakugi, Kei Kamide
Rok vydání: 2023
Předmět:
Zdroj: Hypertension Research.
ISSN: 1348-4214
0916-9636
Popis: The associations among cognitive function, hypertension, and dyslipidemia in older adults are controversial. Therefore, we investigated the associations among cognitive decline, hypertension, dyslipidemia, and their combination in community-dwelling older people in their 70s, 80s, and 90s in the long-term observational Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study. We administered the Montreal Cognitive Assessment Japanese version (MoCA-J) by trained geriatricians and psychologists, and conducted blood testing and blood pressure (BP) measuring by medical staff involving 1186 participants. We performed multiple regression analysis to assess the relationships among hypertension, dyslipidemia, their combination, and lipid and BP levels with cognitive function at the 3-year follow-up after adjusting for covariate factors. At the baseline, the percentage of the combination of hypertension and dyslipidemia was 46.6% (n = 553), hypertension was 25.6% (n = 304), dyslipidemia was 15.0% (n = 178), and that without hypertension or dyslipidemia was 12.7% (n = 151). Conducting multiple regression analysis, no significant correlation was found between the combination of hypertension and dyslipidemia and MoCA-J score. In the group with the combination, high high-density lipoprotein cholesterol (HDL) levels resulted in higher MoCA-J scores at the follow-up (β = 0.06; P P
Databáze: OpenAIRE
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