Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides

Autor:	Anil Misra, Sorour Ramezanpour, Saeed Balalaie, Frank Rominger, Hamid Reza Bijanzadeh, Nahid S. Alavijeh, Mohammad S. Alavijeh
Rok vydání:	2013
Předmět:	Indole test Cell membrane chemistry.chemical_compound medicine.anatomical_structure Chemistry Lipophilicity medicine Organic chemistry General Chemistry Penetration (firestop) Methanol Permeation
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 145:349-356
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-013-1098-0
Popis:	An efficient synthesis of indole-containing pseudopeptides via an Ugi four-component reaction among indolecarboxylic acids, aromatic aldehydes, primary amines, and isocyanides in methanol is described. The lipophilicity of the synthesized compounds was determined using the n-octanol/PBS shake-flask procedure. The lipophilicity studies showed that most of the compounds possess the optimal range of lipophilicity for oral absorption, cell membrane penetration, and blood-brain barrier permeation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15f0da2a9721e5bdebaeab8d201f5e9b https://doi.org/10.1007/s00706-013-1098-0 Zobrazit plný text záznamu Full text from SpringerLink