Controlled study using wireless capsule endoscopy for the evaluation of the small intestine in chronic refractory pouchitis

Autor:	C. Morselli, Giuseppina Liguori, Fernando Rizzello, Gilberto Poggioli, Paolo Gionchetti, G. Di Febo, A. Fabbri, Carlo Calabrese, Massimo Campieri
Rok vydání:	2007
Předmět:	medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Gastroenterology Pouchitis medicine.disease Ulcerative colitis law.invention Surgery Endoscopy medicine.anatomical_structure Capsule endoscopy law Ectasia Internal medicine medicine Duodenum Pharmacology (medical) Pouch Complication business
Zdroj:	Alimentary Pharmacology & Therapeutics. 25:1311-1316
ISSN:	1365-2036 0269-2813
DOI:	10.1111/j.1365-2036.2007.03323.x
Popis:	Summary Background Pouchitis is a common long-term complication after ileal pouch anal anastomosis for ulcerative colitis. Chronic refractory pouchitis is a treatment-resistant condition that affects 5–15% of patients. Aim To test the hypothesis of a small bowel involvement using wireless capsule endoscopy. Material and methods This is a single-blind, prospective, cohort study. Twenty-four patients: 16 were patients with chronic refractory pouchitis and eight, with a macroscopically and histologically normal ileal pouch, were considered as control subjects. Diagnosis of pouchitis was confirmed using the pouchitis disease activity index. All subjects were submitted to wireless capsule endoscopy procedure. Within 2 weeks before wireless capsule endoscopy, patients underwent a pouch endoscopy and a small bowel follow-through. Re-examination of the colonic surgical and histological specimens was also performed. Results One patient with chronic pouchitis was excluded because of incomplete bowel cleaning. At small bowel follow-through of 16 patients, two subjects (13%) showed only a focal ectasia of the middle ileum and a substenosis of the pouch. At wireless capsule endoscopy all the 15 evaluable patients with chronic pouchitis (100%) showed diffuse lesions from duodenum to ileum consisting of aphthae, erosions, erythema, atrophy, cobblestone, deep/fissural ulcers. Conclusions This enteropathy needs further research, and wireless capsule endoscopy could be useful to show involvement of small bowel in patients with chronic pouchitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15e92765173dd47f4f940569859fcdf8 https://doi.org/10.1111/j.1365-2036.2007.03323.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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