Overexpression of PPARγ1 or 2 in Pancreatic β-cells Exacerbates Glucose Intolerance in Diet-induced Obese Mice
| Autor: | Ali Asadi, Michael N. Craig, Michael J. Riedel, Christopher E. Uy, Sarah L. Gray, Robert K. Baker, Jordie D. Fraser, K-Lynn N. Hogh |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
geography ER stress response geography.geographical_feature_category business.industry Endocrinology Diabetes and Metabolism General Medicine medicine.disease Islet Endocrinology Apoptosis Internal medicine Diabetes mellitus Organelle Internal Medicine medicine Unfolded protein response business Diet-induced obese |
| Zdroj: | Canadian Journal of Diabetes. 36:S62 |
| ISSN: | 1499-2671 |
| Popis: | s / Can J Diabetes 36 (2012) S24eS76 S62 glucolipotoxicity and chronic ER stress. Interestingly, double BaxBak knockout resulted in an acute and transient up-regulation of the islet ER stress response. Together, these data suggest that Bax and Bak, both separately and in combination, are important for beta-cell loss in diabetes and have novel roles in the regulation of beta-cell organelle stress upstream of apoptosis execution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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