Synthesis and properties of carbamoyl derivatives of 5-hydroxy-3,3,5-trimethylisoxazolidine

Autor:	Yu. G. Putsykin, Yu. A. Kondrat'ev, V. P. Tashchi, A. F. Rukasov, Yu. A. Baskakov
Rok vydání:	1979
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Hydrochloride Aryl Organic Chemistry Carbon tetrachloride Organic chemistry Methanol Benzene Hydrogen chloride Alkyl
Zdroj:	Chemistry of Heterocyclic Compounds. 15:603-607
ISSN:	1573-8353 0009-3122
DOI:	10.1007/bf00539492
Popis:	The reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with alkyl (or aryl) isocyanates gives N-alkyl(aryl)-carbamoyl-5-hydroxy-3,3,5-trimethylisoxazolidines, which react with methanol in the presence of p-toluenesulfonic acid to give 5-methoxy-1-carbamoyl derivatives of isoxazolidine. When arylcarbamoyl-5-hydroxy-3,3,5-trimethylisoxazolidines are heated in carbon tetrachloride, they are converted to O-arylcarbamoyl-N-(2-methyl-4-oxo-2-pentyl)hydroxylamines, the treatment of which with hydrogen chloride in benzene made it possible to isolate 1,2,6-oxadiazepin-7-ones along with the hydrochloride of the given compounds.
Databáze:	OpenAIRE
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