Screening for HIV-associated distal-symmetric polyneuropathy inCDC-classification stages 1, 2 and 3
| Autor: | C. Heese, S. Böckenholt, Doris Reichelt, K.H. Grotemeyer, B. Kammer-Suhr, Stefan Evers, I.W. Husstedt |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Neurology medicine.diagnostic_test business.industry Physical examination General Medicine medicine.disease Lesion Myelin medicine.anatomical_structure Immunopathology Internal medicine Severity of illness medicine Outpatient clinic Neurology (clinical) medicine.symptom business Polyneuropathy |
| Zdroj: | Acta Neurologica Scandinavica. 101:183-187 |
| ISSN: | 0001-6314 |
| Popis: | Objectives: A total of 670 patients were screened for distal symmetric HIV-associated polyneuropathy during CDC stages 1–3 and its correlation to immunological deterioration. Material and methods: Clinical examinations of 670 patients admitted to the neurological outpatient clinic at the Department of Neurology, University of Munster. Neurophysiological investigations were performed on the sural and peroneal nerve for detection of axonal and myelin lesion. Results: Clinical examination proved progressive; clinical signs and symptoms indicating distal symmetric polyneuropathy from CDC 1 (32%) to CDC 3 (55%). At least one neurophysiological result was impaired in CDC 1 in 25% and in CDC 3 in 45%. Significant correlation between neurophysiological changes and correlations between neurophysiological changes and CDC4+-cells and β-microglobuline were detected for stage CDC 3 C. Conclusion: Results show stage related prevalence of distal symmetric polyneuropathy already in early stages. In late stages of HIV-infection prevalence of distal symmetric polyneuropathy seems to be directly correlated to immunodeficiency syndrome. The pathogenesis of distal symmetric polyneuropathy during HIV-infection is up to now incompletely understood, but results indicate a clear dependency between progressive immunological dysfunction and neuropathy. High active antiretroviral therapy in patients suffering from distal symmetric polyneuropathy is a main topic of future studies. |
| Databáze: | OpenAIRE |
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