Effect of cell lipid composition on the formation of nonspecific antibiotic resistance in alkanotrophic rhodococci
| Autor: | I. B. Ivshina, O. B. Chumakov, M. S. Kuyukina, M. I. Rychkova |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Phosphatidylglycerol
medicine.drug_class Antibiotics Phospholipid Biology biology.organism_classification Applied Microbiology and Biotechnology Microbiology chemistry.chemical_compound Antibiotic resistance chemistry Biochemistry medicine Cardiolipin lipids (amino acids peptides and proteins) Cell envelope Rhodococcus Bacteria |
| Zdroj: | Microbiology. 69:51-57 |
| ISSN: | 1608-3237 0026-2617 |
| DOI: | 10.1007/bf02757257 |
| Popis: | The antibiotic resistance and lipid composition of rhodococci grown in rich organic media with gaseous or liquidn-alkanes were studied. Hydrocarbon-grown rhodococci exhibited an increased resistance to a wide range of antibiotics (aminoglycosides, linkosamides, macrolides, β-lactams, and aromatic compounds). The enhanced antibiotic resistance of rhodococci grown onn-alkanes correlated with an increased content of total cell lipids (up to 14–28%) and saturated straight-chain fatty acids (C16:0, C18:0, C21:0) and was accompanied by the appearance of cardiolipin and phosphatidylglycerol in cells. These lipid compounds are supposed to promote the formation of nonspecific antibiotic resistance in rhodococci by decreasing the permeability of their cell envelope to antibiotics. |
| Databáze: | OpenAIRE |
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