Synthesis and in vitro anticancer evaluation of 2-isopropyl-5-methylphenol Loaded PLGA based iron oxide nanoparticles

Autor:	Ramasamy Elamaran, Balan Rajan, Thandavamoorthy Premkumar, Shanmugam Sathish, Arumugam Madankumar, Mani Gopikrishnan, Thiruvengadam Devaki, Krishnan Gokuladhas, Subramaniyan Jayakumar
Rok vydání:	2014
Předmět:	Materials science Stereochemistry Nanoparticle PLGA chemistry.chemical_compound chemistry Drug delivery Magnetic nanoparticles Nanocarriers Cytotoxicity Iron oxide nanoparticles Food Science Nuclear chemistry Superparamagnetism
Zdroj:	Biomedicine & Preventive Nutrition. 4:137-141
ISSN:	2210-5239
Popis:	For precise delivery of 2-isopropyl-5-methylphenol (IPMP), Poly (lactic-co-glycolic acid) (PLGA) based superparamagnetic nanoparticles loaded with IPMP (IMNPs) were synthesized and characterized. IMNPs with a particle size of 223 ± 20.7 nm were synthesized by solvent evaporation method. Fe 3 O 4 nanoparticles of 33 ± 3.63 nm encapsulated in the PLGA polymer provides the superparamagnetic property to the IMNPs. The entrapment efficacy of Fe 3 O 4 nanoparticles, 2-isopropyl-5-methylphenol and average cumulative percentage release profile of IPMP from the IMNPs were investigated. The magnetic nanocarrier enhanced the stability and activity of IPMP. Release of IPMP from IMNPs occurred in a controlled manner. The cytotoxicity of IMNPs against human hepatoma Hep3B cell line was investigated and the IC 50 value was found to be 20 μg/mL for IMNPs compared to 25 μg/mL for free IPMP. The result showed that IMNPs had significant antitumor activity. Therefore, IMNPs may be considered as an effective anticancer drug delivery system for cancer chemotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15dda123c3bb86eb14c380ca7dd9feb1 https://doi.org/10.1016/j.bionut.2013.12.004 Zobrazit plný text záznamu Full Text from ScienceDirect