Synthesis and Evaluation the Activity of 1, 3, 4-Thiadiazole Derivatives as Antibacterial Agent Against Common Pathogenic Bacteria

Autor:	Alaa Rashad, Asmaa Easa Mahmood, Evon Akram, Shaymaa Naji Daham
Rok vydání:	2019
Předmět:	Imipenem Schiff base Chemistry General Engineering chemistry.chemical_element Pathogenic bacteria Zinc medicine.disease_cause chemistry.chemical_compound Ampicillin medicine Ferric Antibacterial activity Antibacterial agent medicine.drug Nuclear chemistry
Zdroj:	Al-Nahrain Journal of Science. 22:25-32
ISSN:	2663-5461 2663-5453
DOI:	10.22401/anjs.22.1.04
Popis:	Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. Schiff bases react with Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ)) were studied against S. aureus and S . epidermidis as a model of Gram positive, E. coli, P. mirabilis, C. freundii and P. aeruginosa as a Gram negative model to determine activity of synthesized complexes, after subjected them to some tests to confirm the identity of the pathogenic bacteria. Ten antibiotics (Ampicillin and Amoxicillin) have been chosen to investigate the ability of bacterial isolates to resistant the conventional antibiotic. Imipenem have been selected to contrast its efficiency with those of the new compounds because of its high efficiency. The results exhibited higher activity of the new compounds proportional to the chosen antibiotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15d8b3732bcd7785ccffde94c8967d90 https://doi.org/10.22401/anjs.22.1.04 Zobrazit plný text záznamu