Metal Complexes of New Tetraazamacrocyclic Constrained Oxadiazole Ring as Subunits: Synthesis, DNA Binding and Photonuclease Activity

Autor:	H. S. Bhojya Naik, D. Girija, N. Sharath, B. Vinay Kumar, S.M. Pradeepa
Rok vydání:	2012
Předmět:	Polymers and Plastics Absorption spectroscopy Stereochemistry Ligand Oxadiazole General Chemistry Carbon-13 NMR Binding constant chemistry.chemical_compound Crystallography chemistry Octahedral molecular geometry Materials Chemistry Ceramics and Composites Proton NMR Acetamide
Zdroj:	Journal of Macromolecular Science, Part A. 49:139-148
ISSN:	1520-5738 1060-1325
Popis:	A new tetraazamacrocyclic ligand, L (C24H16N12O6) and its complexes of type, [MLCl2] and [CuL]Cl2 (Where M = Co(II), Fe(II); L = N,N′-(benzene-1,3-diyldi-1,3,4-oxadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-oxadiazol-2-yl)amino]acetamide}) were synthesized and characterized by elemental analysis including IR, 1H NMR, 13C NMR, mass and electronic spectral data. An octahedral geometry has been proposed for Fe(II) and Co(II) complexes except the Cu(II) complex which have a square planar environment. The binding property of the complexes with CT-DNA was studied by absorption spectra, viscosity measurement and thermal denaturation studies. The absorption spectral results indicate that the complexes binds with the base pairs of DNA with an intrinsic binding constant Kb of Cu(II), Co(II) and Fe(II) complexes were found to be 4.5 × 104 M−1, 5.7 × 104 M−1 and 2.6 × 104 M−1, respectively in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The photo induced cleavage studies revealed that the complexes show photonucl...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15c840b4cc415021c03ec61893957ccd https://doi.org/10.1080/10601325.2012.642210 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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