Porphyrins with Phenolic Fragments at the Periphery of the Macrocycle as Perspective Antioxidants, Cytoprotectors and Heavy Metal Scavengers

Autor:	Victoria Pavlovna Osipova, Nadezhda T. Berberova, D.B. Shpakovsky, Elena R. Milaeva, M. N. Kolyada
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Reactive oxygen species Antioxidant medicine.medical_treatment Organic Chemistry medicine.disease_cause In vitro Metal chemistry.chemical_compound chemistry In vivo visual_art polycyclic compounds visual_art.visual_art_medium medicine Phenol Organic chemistry Oxidative stress 2 6-Di-tert-butylphenol
Zdroj:	Chemistry of Heterocyclic Compounds. 57:875-888
ISSN:	1573-8353 0009-3122
Popis:	The past few decades witnessed intense research devoted to the antioxidant activity of porphyrins. We review herein recent results of the studies of a series of porphyrins with antioxidant phenol groups in meso positions and an in vitro and in vivo study of their protective effects on free radical-induced damage of biological substances. The antioxidant activity of para-hydroxy-substituted meso-tetraphenylporphines and their metal complexes are summarized. The radical scavenging activity of porphyrins in relation to toxic species, including the highly reactive oxygen species is considered. The protective effects of these porphyrins have been proved in model reactions as well as in vitro and in vivo studies. A special attention is addressed to the polyfunctional porphyrins capable of preventing the toxicity of heavy metals due to antioxidant as well as scavenging ability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15c82a08f56427e72eec1384e1de70dc https://doi.org/10.1007/s10593-021-02995-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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