Studies on the measurement of tissue levels of administered quinacrine and lodoquinacrine

Autor:	N B Ackerman
Rok vydání:	1972
Předmět:	Pathology medicine.medical_specialty Tissue concentrations business.industry Stomach Normal tissue Cancer General Medicine medicine.disease medicine.anatomical_structure Oncology Carcinosarcoma Immunohistochemistry Medicine Surgery business
Zdroj:	Journal of Surgical Oncology. 4:447-453
ISSN:	1096-9098 0022-4790
DOI:	10.1002/jso.2930040507
Popis:	The uptake of administered quinacrine was studied in normal tissues and in Walker. 256 carcinosarcoma tumors implanted in livers and stomachs of rats. Tissue concentrations were measured by a fluorometric technique. The concentration of quinacrine in tumors as compared to that in the liver (T/L ratios) or in the stomach (T/S ratios) was directly related to the size of the tumor. These ratios averaged > 3 in animals with the smallest tumors and < 1 in animals with large tumors. Additional studies comparing uptake of quinacrine and iodoquinacrine suggested that peak T/L ratios occurred at 1 to 3 days with the former compound, with an earlier peak occurring at 1 day with the latter chemical. It is speculated that cancer diagnostic techniques could be developed using tissue measurements, histochemistry, or radioactive scanning of these compounds.
Databáze:	OpenAIRE
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