Serial assessment of humoral immunity in pediatric AML: A prospective study

Autor:	Ritu Gupta, Anuj Kumar Bansal, Surender Kumar Sharawat, Sameer Bakhshi, V Sreenivas
Rok vydání:	2012
Předmět:	Cancer Research Oncology business.industry Humoral immunity Immunology Medicine Prospective cohort study business Pediatric AML
Zdroj:	Journal of Clinical Oncology. 30:9551-9551
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2012.30.15_suppl.9551
Popis:	9551 Background: Humoral immunity has been evaluated in pediatric ALL; data in pediatric AML is lacking. The objectives of this study were to assess humoral immunity on follow-up in pediatric AML patients. Methods: From April 2010-May 2011, 45 consecutive AML patients 1-18 years old were prospectively enrolled with 7 healthy controls. Immunoglobulin (Ig) levels in 45 patients and B-lymphocytes (CD19+) in 29 patients were assessed at diagnosis, post-induction, post-consolidation, 3 and 6 months follow-up and relapse. Results: At diagnosis, Ig levels were higher in patients as compared to healthy controls (IgG, p=0.041; IgA, p=0.07; IgM, p=0.16) while B-cells were lower (p=0.001). Patients with gum hypertrophy had low Ig levels (IgG, p=0.007; IgA, p=0.003; IgM, p=0.06). CR rate was 84.4% (38/45); EFS 40% and OS 58% at 20 months follow-up. Post-induction, there was reduction in IgM (p
Databáze:	OpenAIRE
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