| Autor: |
Kenneth G. Ngwoke, Festus B. C. Okoye, Ogechi O. Anyanwu |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of Medicinal Botany. :7 |
| ISSN: |
2521-3903 |
| DOI: |
10.25081/jmb.2018.v2.957 |
| Popis: |
Inflammatory disorders are linked to the pathogenesis of several diseases. Limitations posed by synthetic anti-inflammatory agents had inspired the need to source for more effective and safer natural alternatives. This study evaluated the anti-inflammatory activities of the twig extracts and fractions of Jatropha Curcas (J. curcas) and also identify the phytocompounds responsible for its anti-inflammatory activities. The methanol/methylchloride extract of J. curcas twig was fractionated into n-hexane, ethyl acetate and butanol fractions. The effects of extracts and fractions of J. curcas twig on xylene induced topical inflammation were evaluated. HPLC and LC-MS of the promising fraction was evaluated. Results showed that the extract exhibited high anti-inflammatory activity at 500 µg/ear (66%) and 250 µg/ear (51%) compared to the positive control, piroxicam with 45% inhibition at 250 µg/ear. Ethyl acetate fraction significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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