Cardiotoxic Profile and Arterial Stiffness of Adjuvant Chemotherapy for Colorectal Cancer
| Autor: | Christodoulos Stefanadis, Christos Georgakopoulos, C. Vlachopoulos, Stella Kyvelou, P Pietri, K Manousou, Dimitris Tousoulis, D Pektasides, A Visvikis |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cardiotoxicity Chemotherapy medicine.medical_specialty Colorectal cancer business.industry medicine.medical_treatment Cancer medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine FOLFOX 030220 oncology & carcinogenesis Internal medicine medicine Arterial stiffness business Prospective cohort study Pulse wave velocity medicine.drug |
| Zdroj: | Cancer Management and Research. 12:1175-1185 |
| ISSN: | 1179-1322 |
| Popis: | Background and Purpose Even though new cancer therapies have improved the overall survival, in some cases they have been associated with adverse effects, including increased cardiotoxicity. The purpose of the present study was to assess the cardiovascular effects of adjuvant chemotherapy for colorectal cancer and mainly the impact on arterial stiffness indices. Material and Methods A total of 70 patients with non-metastatic colorectal cancer who were treated either with FOLFOX (n=16) or with XELOX (n=54) adjuvant chemotherapy were included in the study. All patients were subjected to full cardiovascular evaluation at the beginning and the end of chemotherapy. Arterial stiffness was assessed by means of pulse wave velocity (PWV) and augmentation index (Aix) and full laboratory examinations were conducted prior to, and soon after, the termination of chemotherapy. Results Patients exhibited significantly higher levels of carotid-radial PWV, carotid femoral RWV and Aix post-chemotherapy (p |
| Databáze: | OpenAIRE |
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