Behandlung der therapieresistenten Hypertonie: Antihypertensive Wirksamkeit von Endralazin im Vergleich mit Minoxidil

Autor:	V. Schulz, J. Kindler, W. M. Glöckner, H. G. Sieberth, K. A. Meurer, A. Konrads, P. Vaith
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Initial dose General Medicine Hydralazine Feeling cold Endocrinology Blood pressure Minoxidil Internal medicine Anesthesia medicine Endralazine business Treatment resistant medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 106:1176-1181
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1070477
Popis:	In 16 fo 20 patients with treatment-resistant hypertension endralazine, combined with beta-receptor blockers and diuretics, significantly lowered mean arterial blood pressure from 198/112 mmHg to 148/88 mmHg. The initial dose of endralazine was 2.5 mg three times daily. After this the dosage was increased, at the three to six-day intervals according to antihypertensive action and side effects, to a maximum of 50 mg daily in steps of 5.0--7.5 mg per dose. - In a second series of eleven additional patients with treatment-resistant renal hypertension the blood-pressure lowering effect of hydralazine and minoxidil was compared in an open cross-over trial. The result was in favour of hydralazine. Sodium and water retention was slightly less marked with endralazine. Sleep disorders, increased frequency of feeling cold, moderately severe flushing with red checks and feeling hot occurred but rarely with endralazine and regressed during the period of observation.
Databáze:	OpenAIRE
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